Different brands of levothyroxine may be absorbed differently by your intestines.1 Because levothyroxine
dosing needs to be precise, small differences in dose could result in over- or under-treatment.2
If your brand is switched, it is recommended that you undergo TSH retesting and you may also need to have
your levothyroxine dose adjusted until your TSH levels are within the normal range.1
For these reasons, experts recommend that patients stay on the same levothyroxine preparation throughout
treatment.1
References:
1. Benvenga, S, Carlé A. Levothyroxine formulations: pharmacological and clinical implications of generic substitution. Adv Ther. 2019;36(suppl 2):59-71.
2. Duntas LH, Jonklaas J. Levothyroxine dose adjustment to optimise therapy throughout a patient’s lifetime. Adv Ther. 2019;36(suppl 2):30-46.